A “double negative” in English can also be called “negative concord” and exists in many languages and is fine because language is not math. Also, if you’re into linguistics at all, this whole video is great.
I knew about the project but didn’t know the handbook PLUS a ton of user data is available freely online!
https://www.blackandbrownskin.co.uk/
Conditions esp derm look different on different skins. So important clinicians have exposure and resources on this.
+1 for any drug with any drug
Where “drug” includes supplements, and ask about contraindications with foods.
“Sea lions” are called, literally, “marine wolves” in Spanish.
Especially grapefruit. Everyone on any med or herbal supplement should check about grapefruit.
Cricut machines, the ones that do fancy shape cutouts, RHYME WITH CRICKET.
WHAT.
I also learned this the other day! Some old lady called into talkback radio and was talking about them. To me the most common use of cricket is the sport sort of like your baseball, then a distant second the noisy summer insect.
What is it about grapefruit?
Please notify me immediately if you ever hear someone refer to it as Crick-o.
Ha, is that because Australians shorten everything and add o? Cricko sounds so weird.
P something?
Enzymes that affect absorption and metabolism of stuff
INDEED.
https://www.fda.gov/consumers/consumer-updates/grapefruit-juice-and-some-drugs-dont-mix
“ Many drugs are broken down (metabolized) with the help of a vital enzyme called CYP3A4 in the small intestine. Grapefruit juice can block the action of intestinal CYP3A4, so instead of being metabolized, more of the drug enters the blood and stays in the body longer. The result: too much drug in your body.
The amount of the CYP3A4 enzyme in the intestine varies from person to person. Some people have a lot of this enzyme and others just a little. So grapefruit juice may affect people differently even when they take the same drug.
Although scientists have known for several decades that grapefruit juice can cause too much of certain drugs in the body, more recent studies have found that the juice has the opposite effect on a few other drugs.
“Grapefruit juice can cause less fexofenadine to enter the blood,” decreasing how well the drug works, Huang says. Fexofenadine (brand name Allegra) is available as both prescription and OTC to relieve symptoms of seasonal allergies. Fexofenadine may also not work as well if taken with orange or apple juice, so the drug label says, “Do not take with fruit juices.”
Why this opposite effect? Instead of changing metabolism, grapefruit juice can affect proteins in the body known as drug transporters, some of which help move a drug into our cells for absorption. As a result, less of the drug enters the blood and the drug may not work as well, Huang says.”
Omg I had no idea Allegra was included in this list. I knew about birth control…I guess no grapefruit for me til it snows 
The liver is fucking WILD. That was one of my big take aways in pharma during nursing school, lol!
If my life was an episode of The Office or something there would be a flashback montage to this morning when I literally chased my allergy meds with a grapefruit half.
Maybe a dumb question, but does grapefruit seltzer also do this? I can’t find any reliable info on that.
